Which manifestation is commonly seen in nephrotic syndrome?

Periorbital edema is a commonly observed manifestation in nephrotic syndrome due to the kidney’s impaired ability to filter proteins, leading to proteinuria (excess protein in the urine). This loss of protein causes a decrease in oncotic pressure, allowing fluid to leak from the vascular space into surrounding tissues, resulting in edema. The periorbital area, being well vascularized and with loose connective tissue, often shows swelling first, making it a key clinical sign of nephrotic syndrome.

Other manifestations of nephrotic syndrome can include generalized edema, but periorbital edema is particularly characteristic in children. It is important to recognize this symptom as it can be indicative of kidney function issues and helps guide further evaluation and management of the condition.